TEAM-BY-TEAM 2005 INTERLEAGUE PLAY STATISTICS:
| American League teams | W-L | BA | HR | RUNS | ERA |
| Baltimore Orioles | 8-10 | .278 | 24 | 74 | 4.94 |
| Boston Red Sox | 12-6 | .303 | 26 | 105 | 3.70 |
| Chicago White Sox | 12-6 | .261 | 29 | 98 | 3.46 |
| Cleveland Indians | 15-3 | .293 | 24 | 106 | 2.69 |
| Detroit Tigers | 9-9 | .252 | 14 | 76 | 3.57 |
| Kansas City Royals | 9-9 | .302 | 11 | 101 | 4.81 |
| Los Angeles Angels of Anaheim | 12-6 | 2.81 | 15 | 86 | 2.42 |
| Minnesota Twins | 8-10 | .271 | 23 | 83 | 4.42 |
| New York Yankees | 11-7 | .272 | 15 | 93 | 3.42 |
| Oakland Athletics | 10-8 | .277 | 16 | 85 | 3.23 |
| Seattle Mariners | 10-8 | .283 | 17 | 86 | 3.21 |
| Tampa Bay Devil Rays | 3-15 | .258 | 17 | 73 | 6.35 |
| Texas Rangers | 9-9 | .274 | 37 | 101 | 4.79 |
| Toronto Blue Jays | 8-10 | .234 | 15 | 63 | 3.68 |
| Totals | 136-116 | .274 | 283 | 1,230 | 3.90 |
| National League teams | W-L | BA | HR | RUNS | ERA |
| Arizona Diamondbacks | 8-10 | .274 | 28 | 91 | 4.79 |
| Atlanta Braves | 7-8 | .262 | 14 | 70 | 4.81 |
| Chicago Cubs | 6-9 | .260 | 15 | 57 | 5.15 |
| Cincinnati Reds | 7-8 | .271 | 28 | 83 | 6.16 |
| Colorado Rockies | 6-9 | .247 | 11 | 62 | 4.84 |
| Florida Marlins | 10-5 | .275 | 9 | 71 | 3.76 |
| Houston Astros | 7-8 | .239 | 16 | 53 | 4.81 |
| Los Angeles Dodgers | 5-13 | .235 | 22 | 51 | 4.22 |
| Milwaukee Brewers | 8-7 | .255 | 17 | 58 | 3.94 |
| New York Mets | 5-10 | .237 | 12 | 59 | 4.55 |
| Philadelphia Phillies | 7-8 | .259 | 11 | 59 | 4.50 |
| Pittsburgh Pirates | 5-7 | .255 | 8 | 58 | 4.39 |
| St. Louis Cardinals | 10-5 | .268 | 12 | 73 | 3.27 |
| San Diego Padres | 7-11 | .233 | 18 | 63 | 4.25 |
| San Francisco Giants | 6-12 | .260 | 12 | 77 | 5.74 |
| Washington Nationals | 12-6 | .245 | 14 | 71 | 3.84 |
| Totals | 116-136 | .255 | 247 | 1,056 | 4.56 |
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