| 1. | Robinson Cano | 2B | NYY | 7 | 8 | 608 | 97 | 25 | 41 | 5 | .299 | | | | | | |
| An MVP candidate last season, Robinson Cano posted career-highs across the board with 103 runs, 29 home runs, 109 RBI, and a .381 OBP. The durable second baseman actually tailed off a bit in the second half of the season, however, at 28-years old, Cano remains an elite talent in the Majors. Against the Red Sox last season, Cano hit .371 with 13 RBI in 18 games. |
| 2. | Dustin Pedroia | 2B | BOS | 17 | 152 | 595 | 95 | 18 | 59 | 18 | .293 | | | | | | |
| This one-time AL MVP hopes to return to his productive ways after missing half the 2010 season due to injury. The 27-year old Red Sox star offers a little bit of everything including power, speed, and a high average. Pedroia also stands to gain from the Red Sox acquisition of Adrian Gonzalez, one of the elite sluggers in baseball. |
| 3. | Brandon Phillips | 2B | CIN | 35 | 65 | 609 | 93 | 20 | 46 | 22 | .270 | | | | | | |
| Phillips saw his home run total slide for a third straight season, however, he still remains one of the top second basemen in the game coming off 18 homers, 100 runs, and 16 steals while batting .275 last season. Phillips is particuarly lethal against southpaws with a .294 career average and .505 SLG compared to just a .256 batting clip and .400 slugging against right-handers. |
| 4. | Dan Uggla | 2B | ATL | 55 | 16 | 571 | 80 | 32 | 80 | 4 | .260 | | | | | | |
| 5. | Chase Utley | 2B | PHI | 59 | 97 | 532 | 77 | 24 | 71 | 13 | .272 | | | | | | |
| 6. | Martin Prado | 2B | ATL | 88 | 52 | 587 | 88 | 14 | 45 | 5 | .289 | | | | | | |
| 7. | Ian Kinsler | 2B | TEX | 93 | 122 | 505 | 66 | 20 | 55 | 22 | .276 | | | | | | |
| 8. | Mike Aviles | 2B | KC | 109 | 166 | 513 | 63 | 11 | 26 | 12 | .281 | | | | | | |
| 9. | Kelly Johnson | 2B | ARI | 116 | 41 | 582 | 78 | 21 | 66 | 12 | .266 | | | | | | |
| 10. | Rickie Weeks | 2B | MIL | 119 | 23 | 538 | 80 | 24 | 67 | 12 | .255 | | | | | | |
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