ANAHEIM -- Allowing a season-high three home runs at Angel Stadium, the Angels couldn't keep up with the Chicago White Sox power, and lost, 8-0, Monday in front of 38,561.
The Angels had allowed three home runs total in their previous seven home games, and Monday's eight-run difference marked their largest deficit this season.
Angels starter Ervin Santana surrendered the first runs of the game in the second inning, when Gordon Beckham belted a two-run home run to left field on a first-pitch fastball.
With two outs in the third, Santana gave up three straight hits, including an RBI double to center field by Carlos Quentin, plating Adam Dunn and giving the White Sox a 3-0 lead.
"He couldn't finish in a few innings, but mixed in some pitches," Angels manager Mike Scioscia said. "He had some good sequences, but he had a problem repeating pitches and couldn't put some guys away."
Quentin was part of the White Sox next scoring rally in the fifth inning against Santana, when he hit another RBI double, this time to left field, scoring Alexei Ramirez.
"It's a great feeling when you look up and you have early run support," White Sox starter Edwin Jackson said. "You don't have to be as perfect and you can still stay in the mind frame, attacking hitters. When the offense is swinging like that, you just want to get them back in as quick as possible so they can continue to swing."
Ramirez chased Santana in the seventh inning, when he belted a home run to left field on the first pitch off the inning. In relief of Santana, Trevor Bell then gave up a double and a walk before Quentin rocked a three-run home run to straightaway center field, giving the White Sox a commanding 8-0 lead.
After a stellar four innings in his rain-delayed last start against the Boston Red Sox, in which he didn't give up a hit, Santana allowed five runs on eight hits, while walking two and striking out five. The righty moved to 1-4 on the season with a 4.81 ERA.
"I just didn't have the pitch to finish them off tonight and they came hacking," Santana said. "That is what happens when you make mistakes."
Squandering an opportunity against Jackson in the second, the Angels got two straight singles by Alberto Callaspo and Vernon Wells to lead off the inning. However, on a fly ball to center field by Hank Conger, Callaspo got caught in a rundown between second and third and was tagged out for the double play. Mark Trumbo then grounded out to third to end the inning.
"We didn't get too much going. We tried to be patient and got into some hitting counts, but couldn't do anything with it. He has good stuff and when Jackson is on, he is tough," Scioscia said. "I thought we had opportunities and again with guys in scoring position, we struggled."
In the fourth inning, Wells pulled up lame while running to first base on a ground ball to third. After the game, the Angels placed Wells on the 15-day disabled list with a right groin strain.
The Angels tried to get something started in the sixth, when Erick Aybar singled and Bobby Abreu walked with one out, however Torii Hunter grounded into an inning-ending double play. For Hunter, it marked the 12th double play he has grounded into this season, a new Major League high.
"I hit it hard," Hunter said. "You can't really control where it goes."
While the Angels came into Monday night's game leading the American League in hits (341) and average at .271, the Halos could manage only five hits against Jackson.
"Edwin threw the heck out of the ball tonight," Trumbo said. "He didn't make many mistakes. You can't do a lot and I think the rest of the lineup feels the same way.
"He threw a whole lot of off-speed pitches tonight, a whole lot. He threw enough of them for strikes and has a slider that comes out looking like a fastball. It is really hard to lay off."
Quinn Roberts is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.