Each took the hill during the two-game series in Japan last month, with Hernandez getting a no-decision March 28 after pitching eight innings of one-run ball. Colon earned a win on the 29th after tossing eight innings and surrendering only one run.
The Mariners' right-hander, who hasn't lost to the A's in over three seasons, will also see the team again next Friday in Seattle's home opener.
Yet, facing the same team for his first three starts doesn't bother Hernandez.
"Nope, I don't think it makes any difference. You make good pitches and you'll be out of there," Hernandez said. "It can help me and it could help them, too. They'll have seen me three times, but I'm not going to change anything. I'll just go out there and pitch."
The same could be said for Colon, who continues to build an impressive resume against the Mariners. With a 15-11 record and 4.01 ERA in 30 career starts against Seattle, Colon's win total is tied with John Lackey for the most among active pitchers.
Lights-out at the Coliseum, as well, the right-hander is 5-1 with a 2.14 ERA in seven career appearances (six starts).
"I don't think he's afraid to let you hit the ball, and he knows where it's going, which means he can keep you out of the big part of the ballpark, at times. And here, it doesn't carry as well to the big part, so he's aware of that," A's manager Bob Melvin said. "He's a veteran who has pitched in all kinds of scenarios, and I think he can acclimate to any one of them. His style of pitching, though, would lend to him feeling comfortable in this ballpark."
Mariners: Montero gets start at DH against A's
Jesus Montero was in the Mariners' lineup as the designated hitter on Friday against the A's in his first game since getting hit in the head with a pitch on Monday by Rockies right-hander Edgmer Escalona.
Montero was cleared to play after going through a full workout on Thursday after the Mariners got to Oakland.
"Yeah, everything is good," Montero said. "It took a couple days. The next day, I was feeling dizzy and [had] a lot of headaches. But after that, I was good. It was a big hit."
Since the A's moved to Oakland in 1968, no player has recorded more hits against the Green and Gold than Ichiro Suzuki with 284.
Athletics: Reddick hits third against M's
Manager Bob Melvin decided to pencil Josh Reddick's name into the three hole for Friday's game against the M's, behind Jemile Weeks and Coco Crisp. The move also forced Cliff Pennington into the ninth spot.
"We're going to work the lineup around a little bit and try to find what we feel is the best combination," Melvin said. "We've been doing that all spring. Penny's been hitting, for the most part, second. I want to see what Reddick can do in the third spot. He's shown he can hit left-handers, as well, so we're playing a little bit more to him today."
Eighteen of the Mariners' first 27 games, and 28 of their first 43, will be played on the road.
The last time the A's hit more than three home runs in a game was June 3, 2010, at Boston.