Wilson, 0-3 with a 3.80 ERA in 21 career appearances (four starts) against the Bronx Bombers, will take the hill opposite Phil Hughes for the second act of a three-game set. The Yankees took the series opener, 5-0, behind an exemplary effort from Hiroki Kuroda in his Bronx debut.
New York has now won four straight after being swept by the Rays in its first series of the season, while the Angels have dropped five of their last six games.
Wilson was not spectacular in his Angels debut, against the Twins, but he was effective enough to earn his first victory in a Halos uniform. He surrendered just one run on three hits over seven innings, while battling chilly temperatures and walking four batters.
"It's a team, man -- I don't really care about that," Wilson said about his debut. "I don't care where I pitch. It doesn't matter. As long as we win as a team, that's all that matters."
Wilson will be up against Hughes, who dropped his first decision of the season in a loss at St. Petersburg on Sunday. Hughes threw 99 pitches in just 4 2/3 innings during that outing.
"They did a good job," Hughes said after facing the Rays. "They battled some really key at-bats when I would have liked to have had quick outs and put guys away. I have to do a better job of trying to get some outs early on and throw some better pitches in those situations."
Superstar first baseman Albert Pujols will look to get going at the plate for the Angels. Pujols has gone homerless in his first seven games with his new team -- representing the second-longest streak to start a season in his career -- and is now batting just .222.
"If you look at last year, I don't think his numbers were off the charts in April," Angels manager Mike Scioscia said. "I think there's maybe a couple more variables this year, in terms of coming over to a new league and getting used to a new ballpark, but this guy can hit. He's going to get it together."
Yankees: Not wasting any time
With Nick Swisher's three-run double in the bottom of the first on Friday, the Yankees or their opponent have now scored in the first inning in of each of New York's seven games this season.
The Yankees have scored in the first in their last four contests -- all three against Baltimore, and Friday against the Angels -- for a total of seven runs in that span. Opponents have scored in four first innings, for a total of nine runs.
Yankees relievers have a combined streak of 16 1/3 consecutive shutout frames. The bullpen has a 2.01 ERA -- having allowed five earned runs in 22 1/3 innings -- this season and entered Friday with the fourth-best bullpen ERA in the Majors.
Angels: Slugging against the Yanks
Angels hitters didn't have a great day Friday against Yankees pitchers (going 5-for-29 in the shutout) but the club's current roster is still hitting .298 (534-for-1,788) against New York in their collective careers. The Halos entered the series with a .292 batting average over the last three years at Yankee Stadium, which was best among all Major League clubs.
The Angels are 2-5 for the second time in the last three seasons, having also done so in 2010.
Yankees slugger Alex Rodriguez tied Ken Griffey Jr. for fifth place on baseball's all-time home run list with a solo blast in the third inning, the 630th of his career.
Since Aug. 19, 2011, Angels shortstop Erick Aybar's .333 batting average (50-for-150) is tops among Major League shortstops. His counterpart this weekend, Derek Jeter, entered the weekend second with a .325 average. Jeter went 1-for-4 on Friday, while Aybar was 2-for-4.
Of their first 22 games of the year, the Yankees will play 15 against the three other 2011 American League playoff teams -- Tampa Bay, Texas and Detroit -- and the teams with the next-best records from last season, Boston and Angels. They're 1-3 against those clubs so far.