Friday's series opener saw Jake Peavy hold down the electric Detroit offense, and the White Sox pulled within a half-game of the first-place Tigers in the early standings with a 5-2 victory. Fister, who had been on turn to make this start, was placed on the disabled list with a strained left rib muscle.
Wilk, an 11th-round selection in the 2009 First-Year Player Draft, steadily moved through the ranks in the Minor Leagues and made five relief appearances for the Tigers last year. And now that he's making his first start for the Tigers, he thinks that he'll be able to savor the experience.
"It helps that this isn't my first game and it isn't my first couple days up here in the Majors," he said. "Last time, I was here for a couple days and I got my first outing in on my third day, so now I'm coming up with some experience under my belt. I'm not so nervous like I was last year."
The White Sox have won three straight games and have scored at least four runs in each of those victories, but Floyd will be hoping to rebound from a tough debut. Floyd pitched to a 4-7 record with a 5.66 ERA at home last season compared to an 8-6 record and a 3.41 mark on the road.
Wilk went 24-12 with a 2.58 ERA in 60 career Minor League starts, and he's struck out (263) more than five times as many batters as he's walked (46). The southpaw threw five one-hit innings in his first start for Triple-A Toledo this season, priming him for a chance to step in for Fister.
"It's special to come up either time. Obviously, last year was my debut and the first time I got up as a Major League player," said Wilk. "So that was a lot of fun for me, and that was a great time. This year it'll be a little bit more organized, obviously, because I have a start. So my mom's coming out so she can see me [pitch] for the first time. She's actually seen me in L.A. and Anaheim in uniform but I've never pitched there, so this is actually the first time she's seen me pitch professionally."
Tigers: Jackson's homecoming streak ends
The White Sox managed to keep Austin Jackson off the scoreboard for the first time this season, snapping the Tigers' longest streak in more than two decades. Detroit's leadoff man had scored in each of his first six games, the best streak since Darrell Evans did it in eight games in 1986.
Jackson made it to third base with one out in the eighth inning on Friday -- and he represented the tying run at the time -- but the threat was extinguished on a double play. The center fielder went hitless in the series opener, but he's a career .306 (44-for-144) hitter against the White Sox.
White Sox: Captain steering the ship
Paul Konerko has been his usual steady presence in the middle of the lineup thus far, notching a hit in each of Chicago's first six games. Konerko delivered a key run-scoring single off Max Scherzer in the sixth inning on Friday, and he's batting .435 with six RBIs and four runs scored.
Konkero has had at least two hits in four of his first six games, and he's four home runs away from No. 400 for his career. He'll break a tie with Joe Carter -- 51st all-time -- with his next home run, and he's 21 hits from tying Eddie Collins for the fourth-most hits in franchise history.
Detroit and Chicago combined to strike out 25 times in the series opener, including four by White Sox DH Adam Dunn.