Twins right-hander P.J. Walters will be trying to regain the form that saw him reel off four straight quality starts before stumbling his last time out.
Wood is 0-2 with a 4.56 ERA since stepping into the rotation in place of Chris Volstad and is coming off a tough-luck loss to the Giants on Sunday. He had the misfortune of facing veteran lefty Barry Zito, who was superb for 8 1/3 innings in a 2-0 Giants victory.
Wood gave up three hits over seven innings and struck out seven, one shy of his career high.
"He matched Zito pitch for pitch," Cubs catcher Koyie Hill said after the game. "He kept it under control and gave us a chance. He really did well and executed really well."
It was the his longest and best outing with the Cubs.
"Woody was awesome," Cubs manager Dale Sveum said. "That's as good as I've seen him pitch. He basically threw the ball wherever he wanted."
Walters saw his streak of quality starts come to an end last Saturday, when he struggled through 4 1/3 innings against the Indians. He gave up eight hits and four earned runs and came away with a no-decision in a 7-4 Twins victory.
For the season, Walters is 2-1 with a 3.69 ERA in five starts, and his success was the reason Twins manager Ron Gardenhire left him in to face the Indians' Michael Brantley in a crucial situation in the fifth inning.
The move didn't work, as Brantley delivered a run-scoring single, but Gardenhire said Walters deserved the opportunity to try to get out of the jam.
"He earns that by the way he's pitched up here," Gardenhire said. "It didn't work out for him, but I thought he earned that, so we left him in to face Brantley."
Walters was disappointed that he let a four-run lead slip away.
"I felt like I was just missing a little bit," Walters said. "We scored four runs in the first, and then I came out and walked two guys. That can't happen."
Twins: Mauer might return Friday
Joe Mauer could be back in action on Friday after missing the Kansas City series with a sprained right thumb, an injury sustained on Sunday.
He's expected to be re-evaluated before Friday's game.
Cubs: Sveum, players eager to play at Target Field
This series will mark the Cubs' first visit to Target Field, which opened its doors at the start of the 2010 season. Both Sveum and his players seemed to be looking forward to playing at the new park, as opposed to the Metrodome.
"It's a fantastic stadium," said Sveum, who has been at the ballpark for Interleague games between the Twins and Brewers when he was coaching for Milwaukee. "It's probably one of the best venues there is as far as atmosphere. They built a unique stadium. It plays a little big sometimes, but when the weather is warm, it plays a lot different."
Outfielder David DeJesus, who played at both stadiums during his days in the American League, thinks his teammates will be pleasantly surprised with what Target Field has to offer.
"The guys will be impressed going from the Metrodome to this field," DeJesus said. "It's awesome."
Twins left fielder Josh Willingham is hitting .361 during his 10-game hitting streak after a first-inning single in Wednesday's 4-2 victory over the Royals.
Alfonso Soriano has struck out in each of the five times he has faced Walters during his career.