Milwaukee and San Diego will each send a reliable starter, Shaun Marcum and Edinson Volquez, to the mound, but there hasn't been much consistency beyond them thanks to a number of players going down.
The Padres have made 17 moves to the disabled list involving 15 players this season; the Brewers have seven players out of commission.
"It's a great opportunity for us to see all these guys that we wonder about," Brewers manager Ron Roenicke said. "You have these question marks. 'OK, he's done it in the Minor Leagues, can he do it in the big leagues?'"
In Milwaukee's case, such players as veteran Cody Ransom and Martin Maldonaldo have kept the team afloat. The Brewers have gone 7-3 in their past 10 games, including a series-clinching walk-off victory in the 10th inning over the Cubs on Thursday.
"They come at a cost," Roenicke said of the tests being presented to the young talent, "but they're great opportunities for us to see what we have."
The Padres haven't been as fortunate as they deal with injuries, going 3-13 in their past 16 games. Eric Stults went on the DL on Thursday, joining four starting pitchers already there.
On Thursday, Jason Marquis became the 10th starter this season for San Diego, and on Saturday, Andrew Cashner will become No. 11.
The Padres have struggled to stay competitive throughout all the injuries, dropping their past five series.
Padres: Control an issue for Volquez
Volquez is coming off his seventh quality start, but he was again hurt by a lack of run support and a lack of control.
Six times this season, Volquez has received no runs of support, and that includes three of his past four starts.
The offensive woes have been a problem, but walks haven't helped his cause. Volquez has walked at least four batters in a game five times this season.
"The effort level might have been a little too high," said catcher Nick Hundley. "He's really, really good when he backs off a little. Sometimes less is more."
Brewers: Rodriguez wants to remain with Milwaukee
Francisco Rodriguez is hopeful that he can remain with the Brewers for the rest of the season, despite the team's recent struggles and the possibility it will want to unload salary for prospects.
Rodriguez was traded to the Brewers from the Mets at the non-waiver Trade Deadline last year, but he is hoping his team can turn things around and not be sellers this year.
"We're still there," Rodriguez said. "We haven't played our game yet at the level we're supposed to. We're not too far away, but obviously, we have to get back to .500. That's the main thing. After that, we'll see what's going to happen."
Marcum has won both of the starts he's made -- posting a 1.29 ERA -- since surrendering six earned runs to the Giants on May 22.
The Brewers' Rickie Weeks is hitting .600 with two home runs in his past 10 at-bats against Volquez.