Masterson will try to take advantage of a struggling Twins club that's lost four of their last six games and has given up 34 runs in that span. However, his track record against the Twins -- 1-5 with a 3.61 ERA in 14 appearances and 11 starts -- isn't promising.
He's faced Minnesota once this season -- on June 3 -- and allowed three runs on seven hits and three walks in six innings. The loss dropped the Indians No. 1 starter to 2-5 on the year, but he's since rebounded winning five of his last eight decisions.
"Masterson did a tremendous job," Acta said after his last outing. "He did what we expect our No. 1 guy to do, to go out there and shut down the opposition. ... When he's good, sinking it down, it doesn't matter who you put out there. That was the case today."
Masterson will face Sam Deduno. Deduno, a 29-year-old right-hander, won his first Major League game in his last start, yielding one run in 6 1/3 innings vs. Kansas City.
"I feel pretty happy," said Deduno, who received the game ball that was signed by all of his teammates after the game. "I'm so happy for my first Major League win."
Deduno has now made three starts in the Majors, all coming this season. He's yet to take his first career loss and will try to keep it that way Saturday.
Indians: Perez suffers setback in recovery
• Reliever Rafael Perez was temporarily shut down, the Indians announced Friday. Perez had complained of shoulder fatigue after his latest Minor League outing, so manager Manny Acta decided it best to give him a rest.
"He had another MRI, but it showed great improvement," Acta said. "We're just going to shut him down for three to five days and then re-address the throwing issues."
Perez was 1-0 with a 3.52 ERA in eight outings for Cleveland earlier in the season before injuries forced him out.
• MLB.com has confirmed the Indians are interested in acquiring 28-year-old third baseman Chase Headley from the Padres. According to an ESPN.com report, Cleveland, Baltimore, Oakland and Pittsburgh are the most aggressive teams attempting to deal for Headley.
General manager Chris Antonetti has a policy of not commenting on specific players, but said the team is interested in making a deal.
"If we had the right deal, we would move on that deal," Antonetti said Friday.
Twins: Plouffe lands on DL
• Third baseman Trevor Plouffe hasn't played in a game since July 20 and the club decided his bruised right thumb was serious enough to place him on the 15-day disabled list on Friday. The move is retroactive to July 21. Danny Valencia was recalled from Triple-A Rochester as a replacement.
"It's an opportunity for Danny. Sometimes when an opportunity arises, you take advantage of it, just like Plouffe did," general manager Terry Ryan said. "Here's a chance for Danny to make a good impression. We'll see how he responds."
• Ben Revere enters Saturday's game on a 10-game hitting streak. His career-high is 13 games, which he accomplished from Sept. 13-25 last season. Minnesota has seven players post double-digit hit streaks this year, tied with Texas and San Francisco for the second-most behind Atlanta (9).
Revere is 4-for-19 (.211) with one RBI and no extra-base hits in his career vs. Masterson. Joe Mauer is 6-for-21 (.286) with a double and two RBIs.