The experienced veteran takes on the 26-year-old Hunter on Saturday in the second game of a weekend series with Wild Card implications.
The Athletics are hoping Colon can continue the club's momentum that has seen them win eight of the last nine games, including a 14-9 decision against the Orioles on Friday.
Colon is coming off two nearly identical starts against the Yankees and Rangers that saw him allow four runs on eight hits and a walk with five strikeouts in each.
Hunter, meanwhile, has had more success of late, though he has lacked run support at times. Coming on the heels of a win that saw him pitch 7 1/3 innings of one-run baseball, he came out Monday allowing three runs in seven innings on eight hits that saw him lose to the Indians, 3-1.
Baltimore will be looking to start a hot streak of its own, but will need the run production of its last two games in which the team won once, but scored 15 times. In the three games prior to that, the Orioles scored one run in each, all of which were losses.
Oakland, on the other hand, has given plenty of run support to its pitching staff, scoring 46 runs in five games, winning four.
Athletics: Anderson shows good velocity in rehab start
• Oakland pitcher Brett Anderson, making just his second rehab start, reached 93 mph for Triple-A Sacramento on Friday.
Though he gave up seven hits in four innings that resulted in four runs, A's manager Bob Melvin was happy what the radar gun showed.
"I was surprised he actually hit 93," Melvin said. "Your first couple of times out, there's always that reluctance to really let it go. I know he's a guy that throws in the mid-90s, so I was pleasantly surprised to hear that the velocity was up to that point."
There is still no timetable for Anderson to return to the Majors. He is scheduled to throw a bullpen session and make another rehab start for Sacramento.
Orioles: Wieters expects to be back in Saturday's lineup
• Baltimore catcher Matt Wieters missed Friday's loss to the A's due to biceps soreness that bothered him when he swung left-handed. Wieters said he should be able to play on Saturday.
Manager Buck Showalter said he believed cramping was the issue, caused by high temperatures in Thursday's game that reached the high 90s, but is eager to get him back in the lineup, despite the 1-for-30 slump Wieters is going through.
"No such thing as a good time to not have Matt in the lineup," Showalter said. "We don't look at it as the 's' word. We look at it as not currently performing with the level he has spoiled us with."
• A's pitcher Dallas Braden threw a 20-pitch live batting practice session on Friday in Arizona.
• Orioles second baseman Robert Andino is set to begin a rehab assignment with Triple-A Norfolk Sunday after being sidelined with a left shoulder strain.