Colorado, which trailed the first-place Giants by 22 1/2 games following the Rockies' losses in both games of a Sunday doubleheader against the Phillies, will try to play the role of spoiler this week in Denver.
Vogelsong, 12-7 with a 3.29 ERA, has struggled over his last five starts, surrendering 24 earned runs in 21 1/3 innings, as his ERA has climbed from 2.27 to 3.29.
He gave up six runs in 3 1/3 against the D-backs in his last start.
"I thought he had good stuff," Giants manager Bruce Bochy said. "The pitches might have caught up with him. He was working hard out there and his pitch count got up, and that might have taken a toll."
He'll be up against Rockies right-hander Alex White, who is winless in his career (0-2, 7.90 ERA) against the Giants. White took his eighth loss of the year in his last start despite allowing only one unearned run on two hits, four walks and zero strikeouts in Colorado's 1-0 loss to the Braves.
"I had good stuff," White said afterward. "I made some good pitches, got some guys out and kept us in the game."
It will be White's fourth career appearance (all starts) against San Francisco, and his third of the year.
Rockies: Tulo on the mend
Shortstop Troy Tulowitzki, who has been out since the end of May with a left groin injury that required surgery, is expected to be evaluated after playing Sunday for Double-A Tulsa. Tulowitzki, who went 1-for-4 in the Drillers' final game of the season, could play one or two more rehab games but is expected to rejoin the Rockies this week.
Tulowitzki has played just 47 games for the Rockies this season, batting .287 with eight homers and 27 RBIs.
Giants: How the West is won?
Following the Giants' 4-0 win over the Dodgers on Sunday, the club's remaining 22 games will come within the division. San Francisco is 30-20 against other National League West opponents, going 15-11 at home and 15-9 on the road. The Giants have won 13 of their last 18 games within the division.
The Giants have lost just five times in 73 games when leading after seven innings.
Despite his recent struggles, Vogelsong has not lost since Aug. 19.
After returning from a seven-game road trip that included stops in Atlanta (four games) and Philadelphia (three), the Rockies will be home for only the Giants series and an off-day on Thursday before heading back on the road for seven more (three in San Diego, four in San Francisco).