He won't have to wait long for a shot at revenge, though.
When the Blue Jays face the Red Sox in the second game of a three-game set, Buchholz gets another crack at Toronto and righty Carlos Villanueva, who also started Sunday.
Buchholz (11-6, 4.46 ERA), who is looking to snap a personal three-game losing skid, threw 121 pitches in that game, though an off-day on Monday means he got a little extra rest between starts.
"He made good pitches the whole night -- he deserved better," said Red Sox manager Bobby Valentine, who opted to leave Buchholz in the game in the ninth inning, where he picked up the loss. "He got a little blooper to left with two strikes. He did pretty good."
As for Villanueva, he surrendered three runs on seven hits over six innings, and he got a no-decision. He allowed three runs in 6 1/3 innings in his only other start against Boston this season.
Villanueva (7-5, 3.48 ERA) has tossed six quality starts in his last seven outings, but he's just 1-4 during that time.
Two months ago, the Red Sox and Blue Jays had their sights set on the playoffs, but a mixture of poor play and injury woes got the best of both of them.
When they square off Saturday, they're both looking to stay out of the American League East basement, as the winner will hold onto sole possession of fourth place.
Red Sox: Pedroia may return
Boston second baseman Dustin Pedroia could be back with the Red Sox on Saturday after missing games on Thursday and Friday to be with his wife as she gave birth to their second son.
Though Pedroia didn't travel with the team to Toronto, Valentine said, "he will see us in Toronto."
"They are doing well, mom and baby are doing well," Valentine said. "I don't know about Dustin -- no baseball and no sleep."
Blue Jays: Encarnacion banged up
Edwin Encarnacion missed a game after he was hit in the wrist by a pitch from Felix Hernandez on Thursday, but he may return to the Blue Jays' lineup on Saturday.
His injury isn't serious, and he was able to play after he was hit by the pitch on Thursday, though he felt sore before the game on Friday.
"He's a little sore from getting hit in the wrist," manager John Farrell said on Friday. "More than anything, precautionary, he's out."
In 33 at-bats against Buchholz, Adam Lind is hitting .303 with a pair of home runs. He is the only active Blue Jays player hitting above .222 in five or more at-bats against Buchholz.
Boston's next loss will be their 81st, marking the first time they haven't finished a season above .500 since 1997.
Seven of Boston's last nine games have been decided by two runs or fewer. The Red Sox are 2-5 in those games.
The Blue Jays have never won more than six in a row against Boston in the same season. They had won six straight before their loss Friday.