The dominant performance against the Twins marked the end of a brutal stretch for Sale, who went 1-3 with a 6.60 ERA in five previous road starts.
"I felt good out there -- I felt loose," Sale said after the start. "I felt like, for the most part, I was able to throw all my pitches for strikes. It just went well."
He'll look to continue that momentum on Wednesday against the Royals at Kauffman Stadium as the White Sox, winners of five straight, try to create more separation between themselves and the Tigers in the American League Central. With both teams winning on Tuesday night, Chicago remained three games ahead of Detroit for the top spot.
"He's just good," manager Robin Ventura said of Sale. "Any time he pitches, you feel confident that you're going to have a chance to win the game. Spirits are high when he's pitching just because he's so good."
Bruce Chen will get the ball for Kansas City instead of Luis Mendoza, who will miss the start because of a throat ailment.
While Chen will take the hill a day earlier than expected, he'll still be on normal rest, thanks to an off-day the Royals had on Monday.
The veteran left-hander has gone six or more innings in each of his last six starts, but is still just 2-2 with two no-decisions in that span.
On Friday against the Angels, he allowed five runs on seven hits in 6 1/3 innings for a no-decision.
White Sox: De Aza back for KC opener
Alejandro De Aza was back in the White Sox lineup for Tuesday's series opener against the Royals. He finished 2-for-4 with a home run to start the game.
De Aza sat out the previous two games following an 0-for-9 performance in the first two games of the series with the Twins.
"He just, in Minnesota, didn't look right," Ventura said. "Just tried to get him a day where he could work on it and get back in there. He's fine."
Royals: Gordon selected as Clemente Award nominee
Left fielder Alex Gordon is the Royals' nominee for the 2012 Roberto Clemente Award, which recognizes a Major Leaguer who best represents the game of baseball through positive contributions on and off the field, including sportsmanship and community involvement.
He was recognized before the Royals' game against the White Sox on Tuesday, established as Roberto Clemente Day by MLB.
Since his rookie season in 2007, Gordon has supported the Alex's Lemonade Stand Foundation to raise funds to fight childhood cancer. Gordon has attended the foundation's events, invited children diagnosed with cancer to the ballpark and visited children in hospitals.
"It made sense because of the name, I did a couple of promotions with it and as the years went by, I got more involved. I hope to stay with it and continue to do more for them," Gordon said.
Ventura said that Francisco Liriano will be the starting pitcher in Thursday's series finale against the Royals. It'll be Liriano's second straight start since rejoining the White Sox rotation. He went 2-1 in his first seven games with Chicago -- all starts -- but posted a 5.45 ERA.
Omaha pitching coach Doug Henry arrived on Tuesday to take over as the Royals' interim bullpen coach from Northwest Arkansas pitching coach Larry Carter. In addition, Omaha manager Mike Jirschele took over for Surprise manager Darryl Kennedy as the extra coach permitted on the bench during September.