With postseason hopes still hanging on by a thread for Arizona, it wouldn't mind another offensive outburst like the one that helped it capture a 7-2 win. Another victory would clinch the series at AT&T Park on Wednesday.
The D-backs' offense has been on a roll lately, scoring five or more runs in six of the last seven games. But scoring off Cain as of late has been easier said than done.
Cain, who hasn't dropped a decision since Aug. 6, is coming off back-to-back starts with one run against him.
In the more recent of the two, Cain allowed his single run on just four hits and four walks with eight strikeouts against the Rockies, giving him a career-high 15 wins on the season.
Arizona counters with Wade Miley, who has been a benefactor of the recent run support the D-backs gave him.
Over his last three starts, Miley has been charged with 13 runs in 18 1/3 innings of work, winning the two starts that saw him give up five runs in each.
Last time out, Miley, who leads the club with 16 wins, earned a win over Colorado despite being tagged for five runs on 10 hits with four strikeouts.
The lone loss of his last three starts was a seven-inning outing against San Francisco that saw him give up just three runs on eight hits and a walk with four strikeouts.
D-backs: Skaggs likely benched for remainder of season
Young lefty Tyler Skaggs was in line to get the start Tuesday against San Francisco, but after his recent outings, Arizona manager Kirk Gibson elected to start Josh Collmenter instead.
Skaggs started out strong in his first three Major League starts, but in his last three he's has been roughed up for 14 runs in 12 innings. Decreased velocity also raised concerns for the team, though Gibson said there were other factors to consider.
"Just the way he was trending," Gibson explained. "He feels fine, but his velocity was way down in his last game. The conversation started with the risk versus the reward and we just felt like we didn't have anything to gain by continuing to have him do that."
In six starts for the D-Backs, Skaggs was 1-3 with a 5.83 ERA. He's expected to remain with the team to work on mechanics and conditioning, but likely won't take the field in a game unless it involves extra innings.
Giants: Decision on Cabrera coming soon
Should San Francisco advance far enough in the postseason -- after five games, to be precise -- left fielder Melky Cabrera would be eligible to be reinstated after serving a 50-game suspension for testing positive for testosterone.
Manager Bruce Bochy said Tuesday the club will likely announce its plans for Cabrera in the next few days.
"He needs to know and we need to know," Bochy said of Cabrera, who was hitting .346 on the season.
Catcher Buster Posey said management had not spoken to the players about Cabrera but said Tuesday he felt media questions would present more of a distraction than Cabrera himself would.
With three hits, Aaron Hill was the only D-backs player to pick up more than one hit in the series opener despite the club scoring seven runs.
Posey, who currently has 99 RBIs on the season, and outfielder Hunter Pence, who has 96 of his own, are both vying to reach the 100-RBI mark on the season. If they do so, they would become the first Giants to do so since Barry Bonds in 2004.
Phoenix was named a first-round venue for the World Baseball Classic from March 7-10. Games will be held at Chase Field and Salt River Fields at Talking Stick.