The Blue Jays will look to put two wins together for the first time all season when they take on the Royals on Saturday, and will have to do so without their starting shortstop.
Reyes sustained a sprained left ankle injury in Friday's 8-4 win at Kauffman Stadium. Toronto general manager Alex Anthopoulos said after the game that he expects Reyes to miss one to three months or possibly longer.
"Off the quick look, that's going to be the range," Anthopoulos said. "If it's good news, you are looking at four weeks."
Kansas City ace James Shields will take the mound at home for the first time following road starts against the White Sox and Phillies.
"I'm excited to pitch here," Shields said. "Obviously, since the trade and FanFest, I'm excited to appear here in front of the fans. They've been great so far."
Although he hasn't been in front of the hometown fans yet, Shields has not disappointed in his first couple of games in a Royals uniform. Shields is 1-1 with a 3.75 ERA and 14 strikeouts in 12 innings.
Facing off against the Royals will be Blue Jays right-hander R.A. Dickey, who's struggled mightily to begin the season. Last year's National League Cy Young Award winner has lost both of his starts and has allowed 12 runs (10 earned) in 10 2/3 innings.
"We'll get to a point where there's a good enough sample size that you know what you will get," Dickey said. "But we're not near there yet. There have been plenty of teams that started the year [4-6] and made the playoffs."
Even with his early struggles, Shields knows the challenge his team faces against Dickey.
"He's a tremendous pitcher -- the way he attacks with that knuckleball is pretty special," Shields said. "It should be a battle. You've definitely got to get your A-game going."
The biggest challenge for the Royals comes from Dickey's best pitch, his knuckleball.
"You've just got to try to hit it," manager Ned Yost said. "You can't really prepare any differently because you don't have any idea where it's going."
For Toronto, they'll need Dickey to have his best stuff as the starters continue to have trouble compiling innings. Dickey leads the team in innings, and no starter has worked into the seventh inning.
And even though the Blue Jays have started slowly at 4-6, Yost sees the talent that's sitting in the opposing dugout.
"They improved not only their pitching staff but their team speed, their defense and their offense capabilities, so they've got a nice team over there," Yost said.
Royals: Shields dominant against Toronto
• Shields was 2-0 against Toronto in 2012 with a 1.21 ERA and 25 strikeouts in 22 1/3 innings spanning three starts.
• Despite being near the top-third in runs scored, the Royals have been doing it with small ball. As a team they've only hit four home runs, ranking 26th in the league. Five players have more home runs than Kansas City has a team.
• Friday marked the return of Blue Jays manager John Gibbons to Kansas City. Gibbons served as the Royals' bench coach for three seasons from 2009-11.
Blue Jays: Reyes' injury shuffles defense
• It'll be interesting to see how the Blue Jays decide to set themselves up defensively with Reyes' injury. On Friday, Jose Bautista played third base for the first time since May 27, 2012, where he played four innings in relief. The Toronto slugger did however start 25 games at third in 2011.
• The last time Dickey allowed eight runs in a game was the beginning of a dominating streak for the knuckleballer. Dickey went on to not allow more than three runs in a game for over two months, including a five-game shutout streak from May 27 to June 18.
• Friday marked the first game for waivers claim Casper Wells in a Blue Jays uniform, although the 28-year-old never saw action in the team's win.
• Adding to Toronto's new infield without Reyes is the absence of Maicer Izturis, who missed Friday's series opener after fouling a ball off of his foot against Detroit on Thursday.
Evan Peaslee is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.