The Padres and Rockies last played each other on April 14, when Colorado secured a 2-1 victory and a 6-0 record against their National League West rivals, outscoring them 38-17.
When the two teams begin a four-game series at Coors Field on Thursday, the fourth-place Padres will look to gain some ground on one of the teams ahead of them in the standings.
Those April games all took place before Padres third baseman Chase Headley returned from injury, and a hot streak from him could help change the result.
Headley has been slumping lately, but did have a hit and walked twice in Wednesday's 6-2 win against the Dodgers. His batting average stands at .231, with two hits in his last 28 at-bats. Uncharacteristic for someone who led the league in RBIs last season.
"It's a combination of things. First and foremost, I've got to swing at better pitches," Headley said. "I'm getting myself out. I'm making him [opposing pitcher] throw one quality strike. And there has been a little bad luck mixed in there, too."
While Headley is trying to fix his slump, the Rockies put on a full display of power during Wednesday's 12-4 victory against the Reds.
Carlos Gonzalez (three), Troy Tulowitzki (two) and Todd Helton (one) combined for six home runs, tied for the second most in club history. The Rockies also had a season-high 20 hits, and this all was away from the friendly confines of Coors Field.
The Rockies, who return home winners of four of their last five games and stand two games behind the division-leading D-backs, will send Jhoulys Chacin to the mound. Chacin surrendered five earned runs on nine hits and two walks in six innings in his last start and received a no-decision against the Dodgers. Chacin has not won since April 19.
The Padres counter with Andrew Cashner, who was given an extra two days' rest after throwing a career-high 105 pitches in his last outing, a loss to the Mariners, after allowing three home runs.
"I felt I made a lot of mistakes with my changeup," Cashner said. "They were flat and up in the zone. I've got to be better and not give up home runs."
Rockies: CarGo hits tape-measure homer
The second of Gonzalez's home runs on Wednesday was one of the longest this season.
The Reds announced it went a distance of 476 feet, which would be the longest this year and the longest of Gonzalez's career, but ESPN listed it at 458 feet.
Wednesday was the second time in Gonzalez's career that he hit three home runs, the first came on May 30, 2012, against the Astros.
Padres: Too many swings
The Padres were without first baseman Yonder Alonso for a fourth straight game on Wednesday because the first baseman may have actually hit too much before the game.
Alonso is trying to recover from a right hand contusion, and his hand was sore after taking swings in the batting cage and during batting practice.
"I think the volume [of hitting] might have caught up to him," said Padres manager Bud Black.
• Cashner is making his first career start at Coors Field. He has worked six innings and allowed four runs in each of his last two starts after allowing three runs or fewer in five of his first six starts this season.
• In his third rehab start for the Rockies' Double-A affiliate in Tulsa, Roy Oswalt pitched seven innings, striking out five while allowing seven hits, two of which were home runs in a 5-3 victory over Northwest Arkansas on Tuesday.
Jamal Collier is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.