As the Phillies and Marlins wrap up their three-game set on Thursday, Philadelphia left-hander Cole Hamels will go for career win No. 101, all with the series win on the line.
Standing in his way and trying to net the finale for the Marlins is Henderson Alvarez, who is 2-3 with a 3.62 ERA this season.
Miami manager Mike Redmond said that with ace Jose Fernandez out for the season after undergoing Tommy John surgery, young pitchers like Alvarez have the chance to shine.
"It really is a time where we've got a lot of young guys, and they've all gotten quite a few starts in the big leagues now," Redmond said. "Now we're looking for guys to take that next step and start winning ballgames, and pitching deeper into games.
"Pitching deeper into games is huge for us right now. We have a tough time pitching from the fifth inning on out of our bullpen. For whatever reason, we haven't been able to do that.
"For our starters, that puts a little more pressure on those guys. At the same time, too, they have the stuff to be able to do it. It's there. Now, it's just a matter of pushing through, and getting to that sixth, seventh inning, where they can not only win ballgames, but give ourselves a chance."
In Alvarez's last outing at Marlins Park, he tossed a shutout against the Mets in a 3-0 win on May 6. Since then, he's allowed 10 runs in 10 innings over two starts against the Padres and Giants, but both of those starts were on the West Coast.
That home-road schism is a microcosm of Alvarez's club's performance this season. The Marlins have been dominant at home -- and dominated on the road.
Miami is 18-6 at home, best in the Majors. On the road, the club is 6-17 -- the worst mark in the league.
Hamels, a newly-minted 100-game winner as of Saturday, will try to chip into that league-best home record. With a seven-inning, one-run, 10-strikeout performance to get to the centennial mark, he now sits at 1-2 with a 4.40 ERA on the year.
Hamels, who missed the first few weeks of the season with biceps tendinitis, did not pitch against Miami in the clubs' first meeting in April. Henderson, meanwhile, pitched against the Phillies in that series, going six innings and allowing three runs in a no-decision. The Phillies won that game, 4-3.
Marlins: DeSclafani optioned to Triple-A
The Marlins optioned Anthony DeSclafani to Triple-A on Wednesday, and will add veteran lefty Randy Wolf to the rotation. Wolf will make his first start on Sunday against the Brewers at Marlins Park.
DeSclafani was promoted from Double-A Jacksonville to be an immediate fill-in after Fernandez went down with a right elbow injury that required Tommy John surgery.
DeSclafani made two starts, collecting a win at Dodger Stadium in his Major League debut, giving up two runs in six innings with seven strikeouts. But on Tuesday, in his first start at Marlins Park, the 24-year-old worked 5 1/3 innings, and he gave up five earned runs.
Phillies: Lee's replacement?
The Phillies could announce Cliff Lee's replacement in the rotation Thursday.
Lee is on the disabled list with a strained left elbow. The Phillies say they are optimistic he will miss minimal time, although that is not certain.
It seems likely that Lee's replacement will come from Triple-A Lehigh Valley. A bright spot in Spring Training, David Buchanan is 5-1 with a 3.98 ERA in nine starts with the IronPigs and might well take Lee's spot. Left-hander Greg Smith is also a possibility.
• On Tuesday, Miami's Giancarlo Stanton scored three times despite being hitless in five at-bats. Only seven other times in franchise history has a Marlins player scored that many times without recording a hit.
• The Marlins' 18-6 start at home was the second best in team history, trailing only the 1997 World Series-winning team's 18-5 mark.
David Adler is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.