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Interleague Play Leaders (1997-2008)
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Batting Average (min. 300 at-bats):
| | BA | AB | HITS |
| Pujols, Albert | .350 | 423 | 148 |
| Walker, Larry | .346 | 332 | 115 |
| Ordonez, Magglio | .340 | 580 | 197 |
| Piazza, Mike | .340 | 539 | 183 |
| Erstad, Darin | .335 | 621 | 208 |
| Jeter, Derek | .335 | 836 | 280 |
| Loretta, Mark | .334 | 521 | 174 |
| Matsui, Hideki | .333 | 303 | 101 |
| Suzuki, Ichiro | .331 | 604 | 200 |
| Garciaparra, Nomar | .330 | 557 | 184 |
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Wins:
| | W | L |
| Mussina, Mike | 21 | 13 |
| Garcia, Freddy | 19 | 7 |
| Hernandez, Livan | 19 | 16 |
| Maddux, Greg | 19 | 13 |
| Sele, Aaron | 19 | 9 |
| Buehrle, Mark | 18 | 6 |
| Moyer, Jamie | 18 | 13 |
| Halladay, Roy | 17 | 8 |
| Johnson, Randy | 16 | 12 |
| Leiter, Al | 17 | 11 |
| Mulder, Mark | 17 | 7 |
| Rogers, Kenny | 17 | 7 |
| Santana, Johan | 17 | 7 |
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Hits:
| Jeter, Derek | 280 |
| Rodriguez, Alex | 240 |
| Damon, Johnny | 236 |
| Rodriguez, Ivan | 230 |
| Anderson, Garret | 225 |
| Renteria, Edgar | 219 |
| Guerrero, Vladimir | 216 |
| Dye, Jermaine | 215 |
| Abreu, Bobby | 214 |
| Durham, Ray | 209 |
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ERA (min. 100 innings):
| Santana, Johan | 2.49 |
| Lackey, John | 2.52 |
| Garcia, Freddy | 2.57 |
| Haren, Dan | 2.68 |
| Wells, David | 2.79 |
| Tavarez, Julian | 3.11 |
| Harang, Aaron | 3.12 |
| Moyer, Jamie | 3.12 |
| Halladay, Roy | 3.12 |
| Franklin, Ryan | 3.15 |
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Home Runs:
| Thome, Jim | 66 |
| Griffey, Ken Jr. | 51 |
| Delgado, Carlos | 50 |
| Ramirez, Manny | 47 |
| Bonds, Barry | 42 |
| Konerko, Paul | 42 |
| Palmeiro, Rafael | 41 |
| Giambi, Jason | 40 |
| Sosa, Sammy | 40 |
| Guerrero, Vladimir | 39 |
| Rodriguez, Alex | 39 |
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Saves:
| Rivera, Mariano | 55 |
| Percival, Troy | 40 |
| Hoffman, Trevor | 38 |
| Jones, Todd | 35 |
| Wagner, Billy | 32 |
| Benitez, Armando | 29 |
| Gagne, Eric | 29 |
| Wickman, Bob | 29 |
| Rodriguez, Francisco | 23 |
| Nen, Robb | 22 |
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Runs Batted In:
| Delgado, Carlos | 153 |
| Rodriguez, Alex | 148 |
| Ramirez, Manny | 143 |
| Thome, Jim | 140 |
| Ordonez, Magglio | 133 |
| Dye, Jermaine | 132 |
| Giambi, Jason | 128 |
| Sosa, Sammy | 127 |
| Gonzalez, Luis | 125 |
| Lee, Carlos | 124 |
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Year-by-year Stats:
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History