| Player | Position | Former Team | New Team | Transaction date | Notes | ||
| 301. | Condrey, Clay | RP | MIN | --- | --- | Elected free agency | |
| 302. | Cormier, Lance | RP | TB | --- | --- | Minor league free agent | |
| 303. | Crosby, Bobby | 3B | ARI | --- | --- | Released | |
| 304. | Cruz, Juan | RP | PIT | --- | --- | Released | |
| 305. | Damon, Johnny | OF | TB | --- | --- | --- | |
| 306. | Dessens, Elmer | RP | NYM | --- | --- | --- | |
| 307. | Donnelly, Brendan | RP | PIT | --- | --- | Retired | |
| 308. | Eckstein, David | 2B | SD | --- | --- | --- | |
| 309. | English, Jesse | RP | WSH | --- | --- | Minor league free agent | |
| 310. | Escobar, Kelvim | RP | NYM | --- | --- | --- | |
| 311. | Garland, Jon | SP | LAD | --- | --- | --- | |
| 312. | German, Esteban | IF | TEX | --- | --- | Minor league free agent | |
| 313. | Glaus, Troy | 1B | ATL | --- | --- | Decided to sit out 2011 | |
| 314. | Gonzalez, Enrique | RP | DET | --- | --- | Minor league free agent | |
| 315. | Grudzielanek, Mark | 2B | CLE | --- | --- | Announced retirement | |
| 316. | Guerrero, Vladimir | DH | BAL | --- | --- | --- | |
| 317. | Guillen, Jose | OF | SF | --- | --- | --- | |
| 318. | Guzman, Cristian | 2B | TEX | --- | --- | --- | |
| 319. | Hoffman, Trevor | RP | MIL | --- | --- | Retired | |
| 320. | Howry, Bob | RP | CHC | --- | --- | Announced retirement | |
| 321. | Hudson, Orlando | 2B | CWS | --- | --- | --- | |
| 322. | Kennedy, Adam | 2B | LAD | --- | --- | --- | |
| 323. | LaRue, Jason | C | STL | --- | --- | --- | |
| 324. | Lamb, Mike | 1B | MIA | --- | --- | Minor league free agent | |
| 325. | Lee, Derrek | 1B | PIT | --- | --- | --- | |
| 326. | Lewis, Fred | OF | NYM | --- | --- | Minor league free agent | |
| 327. | Lincoln, Mike | RP | CIN | --- | --- | --- | |
| 328. | Lugo, Julio | 2B | BAL | --- | --- | --- | |
| 329. | Luna, Hector | 2B | PIT | --- | --- | Minor league free agent | |
| 330. | MacLane, Evan | RP | STL | --- | --- | Signed with the Orix Buffaloes of the Japanese Pacific League | |
| 331. | Majewski, Gary | RP | HOU | --- | --- | Minor league free agent | |
| 332. | Manuel, Robert | RP | BOS | --- | --- | Minor league free agent | |
| 333. | Matthews, Gary | OF | CIN | --- | --- | Released | |
| 334. | Medders, Brandon | RP | SF | --- | --- | Minor league free agent | |
| 335. | Mench, Kevin | OF | WSH | --- | --- | --- | |
| 336. | Miles, Aaron | 2B | LAD | --- | --- | --- | |
| 337. | Moehler, Brian | SP | HOU | --- | --- | --- | |
| 338. | Molina, Bengie | C | TEX | --- | --- | --- | |
| 339. | Mora, Melvin | 3B | ARI | --- | --- | --- | |
| 340. | Moseley, Dustin | SP | SD | --- | --- | Minor league free agent | |
| 341. | Mota, Guillermo | RP | SF | --- | --- | --- | |
| 342. | Moyer, Jamie | SP | TOR | --- | --- | Released | |
| 343. | Nippert, Dustin | RP | TEX | --- | --- | Non-tendered | |
| 344. | Ordonez, Magglio | OF | DET | --- | --- | --- | |
| 345. | Park, Chan Ho | RP | PIT | --- | --- | Signed with the Orix Buffaloes of the Japanese Pacific League | |
| 346. | Pavano, Carl | SP | MIN | --- | --- | --- | |
| 347. | Payton, Jay | OF | COL | --- | --- | --- | |
| 348. | Penny, Brad | SP | SF | --- | --- | --- | |
| 349. | Podsednik, Scott | OF | BOS | --- | --- | --- | |
| 350. | Renteria, Edgar | SS | CIN | --- | --- | --- | |
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