 |
Player | Position | Former Team | New Team | Transaction date | Notes | |
| 1. | Aceves, Alfredo | RP | NYY | BOS | 2/09/11 | One-year contract | |
| 2. | Beltre, Adrian | 3B | BOS | TEX | 1/05/11 | Six-year contract | |
| 3. | Cash, Kevin | C | BOS | PHI | 11/19/10 | Minor league contract | |
| 4. | Crawford, Carl | OF | TB | BOS | 12/11/10 | Seven-year contract | |
| 5. | Gomes, Jonny | DH | OAK | BOS | 12/01/12 | Two-year contract | |
| 6. | Gonzalez, Adrian | 1B | SD | BOS | 12/06/10 | Traded for three minor league players and a PTBN | |
| 7. | Hill, Rich | RP | BOS | CLE | 2/07/13 | Minor league contract | |
| 8. | Hoover, Paul | C | PHI | BOS | 1/26/11 | Minor league contract | |
| 9. | Jenks, Bobby | RP | CWS | BOS | 1/21/10 | Two-year contract | |
| 10. | Lopez, Felipe | IF | BOS | TB | 2/02/11 | Minor league contract | |
| 11. | Manuel, Robert | RP | BOS | --- | --- | Minor league free agent | |
| 12. | Martinez, Victor | C | BOS | DET | 11/26/10 | Four-year contract | |
| 13. | Miller, Andrew | P | MIA | BOS | 11/12/10 | Traded for Dustin Richardson | |
| 14. | Ortiz, David | DH | BOS | BOS | 11/05/12 | Two-year contract | |
| 15. | Overbay, Lyle | 1B | ATL | BOS | 1/31/13 | Minor league contract | |
| 16. | Padilla, Vicente | RP | BOS | --- | 1/16/13 | Signed with the JPL Fukuoka SoftBank Hawks. | |
| 17. | Podsednik, Scott | OF | BOS | --- | --- | --- | |
| 18. | Punto, Nick | IF | STL | BOS | 12/14/11 | Signed two-year contract | |
| 19. | Quiroz, Guillermo | C | BOS | SF | 11/20/12 | Minor league contract | |
| 20. | Reyes, Dennys | RP | STL | BOS | 2/09/11 | Minor league contract | |
| 21. | Richardson, Dustin | P | BOS | MIA | 11/12/10 | Traded for Andrew Miller | |
| 22. | Schoeneweis, Scott | RP | BOS | --- | --- | Released | |
| 23. | Sutton, Drew | OF | PIT | BOS | 11/02/12 | Minor league contract | |
| 24. | Uehara, Koji | RP | TEX | BOS | 12/18/12 | One-year contract | |
| 25. | Van Every, Jonathan | CF | BOS | WSH | 12/10/10 | Minor league contract | |
| 26. | Varitek, Jason | C | BOS | --- | 3/01/12 | Announced retirement | |
| 27. | Williams, Randy | RP | CWS | BOS | 12/16/10 | Minor league contract | |
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