Transactions| Date | Transaction | |||
| 5/31/08 | Activated RHP Clay Buchholz from the 15-day disabled list and optioned him to Triple-A Pawtucket. | |||
| 5/30/08 | Placed RHP Daisuke Matsuzaka on 15-day disabled list, retroactive to May 28, with mild right rotator cuff strain and purchased the contract of INF/OF Jeff Bailey from Triple-A Pawtucket. | |||
| 5/25/08 | Sent RHP Clay Buchholz to Triple-A Pawtucket on rehab assignment. | |||
| 5/23/08 | Activated OF Brandon Moss from the 15-day disabled list and optioned him to Triple-A Pawtucket. | |||
| 5/21/08 | Purchased the contract of RHP Bartolo Colon from Triple-A Pawtucket; Optioned RHP Justin Masterson to Triple-A Pawtucket. | |||
| 5/20/08 | Sent RHP Julian Tavarez outright to Triple-A Pawtucket, he had been designated for assignment on May 12, he refused the assignment and is a free agent; Optioned RHP Chris Smith to Triple-A Pawtucket; Recalled RHP Justin Masterson from Double-A Portland; Optioned RHP Justin Masterson to Triple-A Pawtucket. | |||
| 5/19/08 | Optioned RHP Chris Smith to Triple-A Pawtucket. | |||
| 5/18/08 | Recalled RHP Chris Smith from Triple-A Pawtucket; optioned OF Jonathan Van Every to Pawtucket. | |||
| 5/14/08 | Placed RHP Clay Buchholz on the 15-day disabled list with a broken nail on his right middle finger; Recalled OF Jonathan Van Every from Triple-A Pawtucket. | |||
| 5/12/08 | Activated 1B Sean Casey off the 15-day disabled list and designated RHP Julian Tavarez for assignment. | |||
| 5/11/08 | Activated INF Alex Cora from 15-day disabled list and optioned INF Jed Lowrie to Triple-A Pawtucket; Traded RHP Bryan Corey to the San Diego Padres in exchange for a player to be named later or cash considerations. | |||
| 5/5/08 | Placed OF Brandon Moss on the 15-day disabled list, retroactive to May 3, after undergoing an appendectomy; Recalled RHP Craig Hansen from Triple-A Pawtucket. | |||
| 5/1/08 | Sent RHP Bryan Corey outright to Triple-A Pawtucket, he had been designated for assignment on April 29. | |||