| Date | Transaction | |||
| 6/27/01 | Mendy Lopez: The contract of Mendy Lopez, INF, was purchased from Triple-A New Orleans. | |||
| Joe Slusarski: Joe Slusarski, RHP, was optioned to Triple-A New Orleans. | ||||
| Jay Powell: Jay Powell, RHP, was traded to Colorado for Ron Villone, LHP, and cash considerations. | ||||
| 6/24/01 | Tony McKnight: Tony McKnight, RHP, was optioned to Triple-A New Orleans. | |||
| 6/23/01 | Jose Lima: The Astros traded Jose Lima, RHP, and cash to the Detroit Tigers in exchange for Dave Mlicki, RHP. | |||
| Kent Bottenfield: Kent Bottenfield, RHP, was moved to the 60-day disabled list. | ||||
| Orlando Merced: Orlando Merced, OF, was placed on the 15-day disabled list. | ||||
| Scott Servais: The contract of Scott Servais, C, was purchased from Triple-A New Orleans. | ||||
| Tim Redding: Tim Redding, RHP, was recalled from Triple-A New Orleans. | ||||
| 6/19/01 | Glen Barker: Glen Barker, OF, was optioned to Triple-A New Orleans. | |||
| Billy Wagner: Billy Wagner, LHP, was activated from the 15-day disabled list. | ||||
| 6/12/01 | Tony McKnight: Tony McKnight, RHP, was recalled from Triple-A New Orleans. | |||
| Kent Bottenfield: Kent Bottenfield, RHP, was placed on the 15-day disabled list. | ||||
| 6/4/01 | Bill Spiers: Bill Spiers, INF, was moved from the 15-day disabled list to the 60-day disabled list. | |||
| Joe Slusarski: The Astros purchased the contract of Joe Slusarski, RHP, from Triple-A New Orleans. | ||||
| Billy Wagner: Billy Wagner, LHP, was placed on the 15-day disabled list. | ||||
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