| Date | Transaction | |||
| 3/31/01 | Placed RHP Rich Loiselle on the 60-day disabled list | |||
| Placed 1B/OF Alex Hernandez on the 60-day disabled list | ||||
| Placed RHP Jason Schmidt on the 15-day disabled list | ||||
| Placed RHP Francisco Cordova on the 15-day disabled list | ||||
| Placed RHP Kris Benson on the 15-day disabled list | ||||
| Placed IF Mike Benjamin on the 15-day disabled list | ||||
| Purchased the contract of RHP Marc Wilkins from Triple-A Nashville | ||||
| Purchased the contract of IF/OF John Wehner from Triple-A Nashville | ||||
| Optioned IF Warren Morris to Triple-A Nashville | ||||
| Optioned OF Chad Hermansen to Triple-A Nashville | ||||
| 3/28/01 | Acquired RHP Omar Olivares from the Oakland Athletics in exchange for a player to be named later | |||
| 3/26/01 | Optioned C Humberto Cota to Triple-A Nashville | |||
| 3/25/01 | Optioned LHP Brian O''Connor to Triple-A Nashville | |||
| 3/23/01 | Signed LHP Scott Karl to a minor league contract | |||
| 3/20/01 | Unconditionally released LHP Dan Serafini | |||
| 3/19/01 | Optioned C Craig Wilson to Triple-A Nashville | |||
| 3/12/01 | Optioned LHP Dave Williams to Single-A Lynchburg | |||
| Optioned RHP Chris Spurling to Double-A Altoona | ||||
| Optioned OF Tike Redman to Triple-A Nashville | ||||
| Optioned LHP Wilson Guzman to Double-A Altoona | ||||
| Optioned LHP John Grabow to Double-A Altoona | ||||
| Optioned OF J.J. Davis to Double-A Altoona | ||||
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