| Date | Transaction | |||
| 9/18/04 | Activated RHP Jay Witasick from the 15-day disabled list. | |||
| 9/16/04 | Acquired SS Alex S. Gonzalez and cash from the Expos for a player to be named later or cash; designated RHP Marty McLeary for assignment. | |||
| 9/13/04 | Recalled OF Freddy Guzman, C Humberto Quintero and RHP Brian Sweeney from Triple-A Portland. | |||
| 9/10/04 | Purchased the contract of LHP Mike Bynum from Triple-A Portland. | |||
| 9/6/04 | Recalled OF Xavier Nady and RHP Justin Germano from Triple-A Portland, optioned RHP Dennis Tankersley and OF Freddy Guzman to Portland. | |||
| Purchased the contract of RHP Andy Ashby. | ||||
| 9/4/04 | LHP Sterling Hitchcock announced his retirement from the Padres. | |||
| 9/1/04 | Purchased the contract of OF Kerry Robinson from Triple-A Portland; recalled C Miguel Ojeda from Portland and reinstated him from the 15-day disabled list; recalled RHP Antonio Osuna from Single-A Lake Elsinore and reinstated him from the 15-day disabled list. | |||
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