CLEVELAND -- Grady Sizemore was asked what it means to get a run on the board when the opposing pitcher has only thrown "four or five" pitches.

"Two, actually," Sizemore replied with a smile.

He was referring, of course, to the leadoff homer he cranked out Wednesday night against A's right-hander Joe Blanton. It came on the second pitch of the bottom of the first, and it was Sizemore's third leadoff homer of the season and 14th in his career.

In just his fifth big league season, Sizemore is only four leadoff homers away from Kenny Lofton's club record of 18.

"I like it," Sizemore said. "I'm not really trying to go up there and do it. But to get the offense going and maybe throw the pitcher off ... I'm not a pitcher, so I can't say how it affects him ... but maybe it gets him rattled, and you go from there. Any time you can get a run on the board early, it helps your team, regardless of whether it's a homer or an RBI single."

Sizemore's main concern, he said, is trying to get on base to create some offense. Lately, he's been doing so with a penchant for going to the opposite field. His homer off Blanton, in fact, went out to left-center, and he went on to fly out to left twice in Wednesday night's game.

"He hit that [home-run] ball to left-center like a right-hander does," manager Eric Wedge said. "Those are all good indicators."

But going to the opposite field is not necessarily by design.

"You always try to spray the ball as much as you can," Sizemore said. "I'm just trying to go with the pitch, really. I aim for the middle of the field."