Carlos Guillen left the game after hitting a two-run double. (AP)

DETROIT -- Carlos Guillen went from the hero at the plate to pulled off the basepaths on Sunday with a sore right Achilles tendon. On Monday, he was back at the plate, this time as the designated hitter.

Though Guillen seemed to be favoring his right foot to some degree as he ran the bases on his second-inning single on Monday, it clearly didn't hamper him at the plate. He said he felt much better Monday morning, and manager Jim Leyland wouldn't rule out putting him back in left field Tuesday.

Having Guillen available was a big plus for Leyland, who tried to get as many left-handed hitters as he could into his starting lineup against the White Sox and right-handed starter Gavin Floyd. Josh Anderson took Guillen's place in left field, while switch-hitting Ramon Santiago started at shortstop.

Monday's lineup had another adjustment late in the morning, when catcher Gerald Laird was scratched. He was feeling ill this morning, according to Leyland. Matt Treanor replaced him in the lineup. The series of shifts left Santiago batting sixth in the starting lineup for the first time in his career.

And the lineup move paid off, with Santiago hitting a big three-run homer in the third inning.

In other injury news, Leyland said there were no reports of any soreness in reliever Joel Zumaya's shoulder after his rehab outing Saturday, which is good news for the Tigers. Zumaya is now set for another outing at Class A Lakeland, where he gave up two walks and an RBI hit Saturday.

"As long as he's healthy, he's moving forward," Leyland said.

Meanwhile, Jeremy Bonderman was scheduled to throw Monday for the first time since his rough Spring Training outing against the Braves on March 29. He had been shut down for therapy on his shoulder over the past week.