GOODYEAR, Ariz. -- Making his final start of Spring Training, Cubs right-hander Carlos Zambrano labored with his command in a 4-3 loss to the Indians on Monday afternoon at Goodyear Ballpark.

Zambrano, who is penciled in as Chicago's No. 2 starter to open the season, issued five walks over five innings. Along the way, Big Z relinquished four runs (three earned) on four hits with a pair of strikeouts.

Indians catcher Carlos Santana got things rolling for the Tribe with a single to left field in the second inning and crossed the plate on a sacrifice fly from Matt LaPorta. Orlando Cabrera contributed an RBI double in the fourth inning and the Indians tacked on two more runs in the fifth.

Cleveland right-hander Carlos Carrasco, his team's No. 2 starter as well, pieced together six solid innings in his final tuneup for the regular season. Carrasco yielded just one run on three hits in his time on the hill, adding five strikeouts without issuing a walk.

Chicago's lone run against Carrasco came in the second inning, when first baseman Carlos Pena launched a solo homer to deep right-center field -- his third blast in Cactus League play. For Carrasco, it represented the seventh long ball he has surrendered in 22 2/3 innings this preseason.

The Cubs mounted a rally against Indians closer Chris Perez in the ninth. Tyler Colvin was hit by a pitch and scored on a double by Pena to trim Cleveland's lead to 4-2. Aramis Ramirez scored from third base on a wild pitch to pull Chicago within a run.

After walking Darwin Barney with two outs, Perez moved to the side of the mound and squatted down due to being light-headed. He was met on the hill by manager Manny Acta and head athletic trainer Lonnie Soloff and was promptly pulled from the game. Vinnie Pestano entered in relief and retired Koyie Hill to end the game.

Indians center fielder Grady Sizemore, who is making his way back from microfracture surgery on his left knee, served as the designated hitter in his fourth Cactus League game. Sizemore finished 0-for-3 with two walks, a run scored and a stolen base.

Up next for Cubs: Matt Garza makes his final spring start on Tuesday when the Cubs play their last Cactus League game, hosting the D-backs at HoHoKam Park at 3:05 p.m. CT. Jeff Baker is expected back in the lineup and at second base. Baker has been slowed by a tender left hamstring, but the Cubs want him to lead off against lefty Joe Saunders. The game will be broadcast live on Gameday Audio.

Up next for Indians: Right-hander Justin Masterson, who was recently named the Indians' No. 3 starter, will take the mound on Tuesday as the Tribe takes on the Reds in a 3:05 p.m. ET tilt at Goodyear Ballpark. Fans can listen to the game live with Gameday Audio. It will be Cleveland's last Cactus League contest before departing Arizona for Wednesday's exhibition game against Triple-A Columbus in Columbus, Ohio.