Four months after Busch Stadium plays host to a game between an English Premier League teams, the venue will host its first college football game.

Rivals Southeast Missouri State University of the Ohio Valley Conference and Southern Illinois University of the Missouri Valley Conference will kick off in St. Louis on Sept. 21 at 1 p.m. CT. The schools will meet for the 81st time.

Tickets are slated to go on sale on June 3. More information can be found at cardinals.com/football.

On May 23, Manchester City Football Club and Chelsea Football Club will play a friendly, the first non-baseball professional sporting event at the ballpark.